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Malaria Pills & Malaria Prevention in Singapore

Malaria isn't found in Singapore, but it remains a serious risk in more than 90 countries. It is also largely preventable. Our doctors advise on complete malaria prevention for your destination and prescribe the right malaria pills — in a single travel consultation, alongside any vaccines you need.

PrescriptionDoctor's advice needed
4–6 wksSee us before travel
No vaccineTablets, not a jab
AccessibleClinics across Singapore
Antimalarial tablets packed for a safari trip
The disease

What is malaria?

Malaria is a potentially life-threatening illness caused by Plasmodium parasites, spread through the bite of an infected female Anopheles mosquito. Once inside the body, the parasite multiplies in the liver before infecting red blood cells — which is when symptoms begin.

Symptoms typically appear 10 to 15 days after infection, but can surface weeks or months after you return home. Untreated, malaria — particularly Plasmodium falciparum — can lead to organ failure, coma or death. Early diagnosis and treatment are critical.

Symptoms to watch for

  • High fever, chills and sweating
  • Headache, fatigue and body aches
  • Nausea, vomiting or diarrhoea
  • Symptoms 10–15 days after infection — sometimes months later
Malaria prophylaxis

What are malaria pills, and how do they work?

Malaria pills — also called malaria tablets, antimalarials or malaria prophylaxis — are prescription medicines that stop the Plasmodium parasite from multiplying in your body if you are bitten. They do not repel mosquitoes or prevent bites.

They are started before you travel so protective levels build up in your bloodstream, taken throughout your trip, and continued for a period after you return to clear any parasites still incubating.

There is no malaria vaccine for travellers. Malaria vaccines (RTS,S and R21) are used in routine childhood immunisation in some endemic African countries, so for travel, prevention rests on tablets plus avoiding bites.

Why malaria prevention matters

  • Malaria can be fatal — but is largely preventable
  • Present in over 90 countries worldwide
  • No travel vaccine exists — tablets are the mainstay
  • Symptoms can appear months after you get home
  • Taken correctly, prophylaxis greatly reduces your risk
Know your risk

Which destinations have malaria risk?

Risk varies by country, region, season and how rural your itinerary is. Our doctors assess the exact cities, towns and nature areas you plan to visit.

Africa

  • Much of sub-Saharan Africa
  • Kenya, Tanzania, Uganda
  • Ghana, Nigeria
  • DR Congo
  • Highest risk region

South Asia

  • Parts of India
  • Bangladesh
  • Pakistan
  • Afghanistan

Southeast Asia

  • Rural Indonesia
  • Myanmar, Cambodia, Laos
  • East Malaysia (e.g. Sabah)
  • Mainly rural & forested areas

South America

  • The Amazon basin
  • Peru, Brazil, Colombia
  • Bolivia, Venezuela

Pacific Islands

  • Papua New Guinea
  • Solomon Islands
  • Vanuatu

Planning your trip

  • Risk differs city vs rural
  • Season affects transmission
  • Length of stay matters
  • We assess your itinerary

Malaria risk maps change. Always confirm current advice for your destination with your doctor before you travel.

Your options

Which malaria tablets are used in Singapore?

Each antimalarial has its own dosing pattern, side effects and suitability. Your doctor will recommend one for you and give you a precise schedule.

Atovaquone–proguanil

Malarone®

A well-tolerated daily tablet with few side effects, and the shortest course after you return — often the preferred choice for shorter trips.

  • Taken once daily
  • Started 1–2 days before travel
  • Continued 7 days after returning
  • Not suitable in severe kidney impairment

Doxycycline

Antibiotic · lower cost

An affordable daily tablet that also offers some protection against certain other travel infections. Can make skin more sensitive to sunlight.

  • Taken once daily
  • Started 1–2 days before travel
  • Continued 4 weeks after returning
  • Avoid in pregnancy and young children

Mefloquine

Lariam® · weekly

A weekly tablet, convenient for longer stays — but unsuitable for some people, and started further ahead so tolerance can be checked.

  • Taken once weekly
  • Started 2–3 weeks before travel
  • Continued 4 weeks after returning
  • Avoid with some mental health & neurological conditions

Timings above are typical patterns, not a prescription. The medicine that's right for you — and your exact start, duration and finish dates — depend on your destination, medical history, other medications, age, and whether you are pregnant or breastfeeding. Malaria pills are prescription-only in Singapore; please see our doctors for personalised advice.

Before you start

Side effects & who should not take malaria pills

Most travellers tolerate antimalarials well, but they aren't right for everyone.

Possible side effects

  • Mild stomach upset, nausea or vomiting
  • Headache, dizziness or light-headedness
  • Increased sun sensitivity (doxycycline)
  • Vivid dreams or mood changes (mefloquine)
  • Rarely: rash, allergic reaction or marked mood change — seek help promptly

Tell your doctor if you

  • Are pregnant, breastfeeding or trying to conceive
  • Are travelling with infants or young children
  • Have kidney or liver problems
  • Have epilepsy, depression, anxiety or another mental health condition
  • Take other medicines, or have had a reaction to an antimalarial before

Fever after travel is an emergency

Malaria can develop weeks or months after you return — even if you took your tablets correctly. If you develop a fever during or after travel to a malaria area, seek medical attention immediately and tell the doctor exactly where you travelled.

Complete protection

The ABCD of malaria prevention

Tablets are only part of malaria prevention. Avoiding bites matters just as much.

A

Awareness of risk

Know whether malaria occurs where you're going, and in which areas and seasons.

B

Bite prevention

Insect repellent with at least 20% DEET, long sleeves and trousers at dusk and dawn, and a treated bed net.

C

Chemoprophylaxis

Take the right malaria pills, exactly as prescribed — including the full course after you return.

D

Diagnose promptly

Any fever during or after travel needs urgent medical attention. Always say where you went.

How it works

Getting your malaria pills

One consultation covers your malaria prevention and any travel vaccines you need.

1. Tell us your trip

Destination, dates, itinerary and how rural you'll be.

2. Travel health review

We check your medical history, medications and any allergies.

3. Prescription & schedule

The right antimalarial, with clear instructions on when to start and stop.

4. Travel vaccines too

Any jabs your destination needs, arranged in the same visit.

Come and see us about 4–6 weeks before you fly. Antimalarials must be started before departure — mefloquine several weeks ahead — and travel vaccines need time to take effect. Travelling sooner? Come anyway; we can still help.

Cost

How much do malaria pills cost in Singapore?

Antimalarials are priced per tablet, so the total depends on the medicine prescribed and the length of your trip — remember the course continues after you return. A consultation fee applies. Please contact us for current pricing before you travel.

 Ask us about malaria pills
Good to know

Malaria pills & malaria prevention FAQs

What are malaria pills?
Malaria pills — also called antimalarial tablets or malaria prophylaxis — are prescription medicines taken before, during and after travel to a malaria-risk area. They don't stop you being bitten. They stop the malaria parasite from multiplying in your body if an infected mosquito does bite you.
Do you need a prescription for malaria pills in Singapore?
Yes. Malaria pills are prescription-only medicines in Singapore. A doctor must assess your destination, itinerary, medical history and any other medications before prescribing, so you cannot buy them over the counter.
Can a GP prescribe malaria tablets?
Yes. Our GPs prescribe antimalarials after a short travel consultation, in which we review where you're going, how long you'll be there, how rural your itinerary is, and your medical history.
Is there a malaria vaccine?
Not for travellers. Malaria vaccines (RTS,S and R21) are used in routine childhood immunisation in some malaria-endemic African countries, but they are not available or recommended for travellers. For travel, malaria prevention relies on antimalarial tablets plus bite prevention.
Which countries require malaria pills?
Malaria risk is present in much of sub-Saharan Africa, parts of South and Southeast Asia (including rural Indonesia, Myanmar, Cambodia, Laos and East Malaysia), the Amazon basin in South America, and some Pacific Islands such as Papua New Guinea. Risk varies by region, season and how rural your trip is — our doctors will assess your exact itinerary.
How soon before travel should I start malaria pills?
It depends on which antimalarial you're prescribed — typically 1–2 days before for atovaquone-proguanil and doxycycline, and up to 2–3 weeks before for mefloquine. Come and see us around 4–6 weeks before you fly so there's time to start the right course, and to get any travel vaccines.
When do I stop taking them?
Not on the day you land home. The course continues after you return — typically 7 days for atovaquone-proguanil and 4 weeks for doxycycline and mefloquine — to clear any parasites still incubating. Stopping early is one of the most common reasons malaria prophylaxis fails.
What if I miss a dose or vomit after taking it?
If you remember a missed dose within a few hours, take it. If it's nearly time for the next dose, skip it — don't double up. If you vomit shortly after taking a tablet, you may need to repeat the dose. Missing doses reduces your protection, so take it at the same time each day and check with us if you're unsure.
What are the side effects of malaria pills?
Most people tolerate them well. Common effects include mild stomach upset, nausea, headache or dizziness; doxycycline can increase sun sensitivity; mefloquine may cause vivid dreams or mood changes. Serious reactions are uncommon. Seek medical attention promptly if you develop a rash, swelling, breathing difficulty or significant mood changes.
Who should not take malaria pills?
Certain antimalarials are unsuitable in pregnancy or breastfeeding, in young children, in people with kidney impairment, epilepsy, or some mental health conditions, and with certain other medications. Tell your doctor your full medical history so a safe option can be chosen for you.
Are malaria pills 100% effective?
No antimalarial is completely effective, which is why bite prevention still matters. Taken correctly alongside repellent, covered clothing and a treated bed net, malaria pills greatly reduce your risk of serious illness.
How much do malaria pills cost in Singapore?
Antimalarials are priced per tablet, so your total depends on which medicine you're prescribed and how long your trip is — the course continues for days or weeks after you return. A consultation fee also applies. Contact us for current pricing before you travel.
What if I get a fever after travelling?
Malaria can appear weeks or even months after you return, and can occur even if you took your tablets. Any fever during or after travel to a malaria area is a medical emergency until proven otherwise. See a doctor promptly and tell them exactly where you travelled.
Do I need travel vaccines as well?
Often, yes. Malaria is prevented with tablets, not a vaccine, but malaria-risk destinations frequently also call for travel vaccines such as typhoid, hepatitis A, yellow fever or Japanese encephalitis. We can plan your malaria prevention and travel vaccines in a single consultation.
Related

Travel vaccines you may also need

Travelling soon? Let's get you protected.

Book a travel consultation at any of our clinics. We'll advise on malaria prevention and prescribe malaria pills for your destination, all in one visit.

Book a travel consultation

Sources

The requirements and recommendations on this page are drawn from official Singapore government sources:

This page is general information, not medical advice, and requirements can change. Always confirm the current position with the relevant Singapore government agency, or speak to our doctors about your own circumstances.